Sunderland will aim to continue their unbeaten home record this season against a Liverpool side who lost late on at home to Manchester City on Sunday.
BBC Sport examines some of the key themes going into their meeting at the Stadium of Light.
Sunderland will attempt to bounce back from a competitive, if ultimately comprehensive defeat, at Arsenal on Saturday back in the secure surroundings of the Stadium of Light.
The Black Cats' current unbeaten run of 12 Premier League home games is the longest of any side, most recently beating fellow promoted side Burnley on 2 February. Manchester City and Arsenal have both already failed to win on Wearside this season.
It's the longest run by a promoted side from the start of a top-flight season since 1978, when Nottingham Forest remained unbeaten in all 21 home outings enroute to winning the league title.
Next on the agenda for Regis le Bris' side is an attempt to arrest a winless run against Liverpool – and the time could be ripe to do so.
Sunderland have not beaten the Reds in 11 Premier League meetings, since a 1-0 home win 14 years ago, but all three of Liverpool's Premier League losses in this fixture have come away from home. The visitors will also be without key midfielder Dominic Szoboszlai following his dismissal in Sunday's defeat.
Erling Haaland's winner at the weekend was the sixth stoppage-time goal Arne Slot's side have conceded in the Premier League this season, with only Leeds United and Newcastle United letting in more.
And this one proved particularly costly, with Liverpool five points off fifth place. It is the kind of setback that is particularly unwanted on home soil when Liverpool are struggling so badly on the road.
They have won just two of their past 10 away matches (D3, L5), conceding 21 goals in total this season – which is more than bottom club Wolves.
Sunderland are winless in their eight most recent midweek Premier League games (D3, L5) – although their only goal during this run came in a 1-1 draw at Anfield in December.
Chemsdine Talbi scored on that occasion and he could become the first Sunderland player to score in both league meetings against Liverpool since Stan Cummins 45 years ago.