Toppin finished with 20 points and eight rebounds before needing assistance to leave the court.
Coach Grant McCasland said he was disappointed but noted the team regrouped late in the game.
Texas Tech's JT Toppin Injures Right Leg vs. Arizona State
Texas Tech star JT Toppin suffered a lower right leg injury during Tuesday night's loss to Arizona State. The junior forward, averaging nearly 22 points per game, went down late in the second half.