Scotland coach Greg Townsend has shuffled his pack for the Wales clash, bringing in Dave Cherry, Max Williamson and Matt Fagerson to replace George Turner, Jamie Ritchie and Jack Dempsey. The Tolouse fullback Blair Kinghorn is fit and ready to feature after recovering from injury.
The match kicks off at 4.40pm GMT at Principality Stadium, following Scotland's impressive victory over England in their previous Six Nations fixture.