Lautaro and Soulé will play their first match in over a month for Inter, who have lost their last three league games. Roma travel to Milan without Dybala, Dovbyk, and Koné but feature Bryan Cristante and Pellegrini.
Inter (3-5-2) features Acerbi, Barella, and Dimarco, while Roma (3-4-2-1) starts Svilar, Mancini, and Pellegrini. The match kicks off at 20:45 CET and is available on TNT Sports, DAZN, and Paramount+.