Before the latest round of Premier League fixtures, here is all the key injury news alongside essential Fantasy Premier League statistics.
The gameweek kicks off on Tuesday evening with four matches - here is the full fixture list.
This article will be updated as Premier League managers give their news conferences.
For more FPL help, don't miss our regular Friday Q&A from 15:30 GMT live on the BBC Sport website, with one of our four experts answering your questions
Tuesday
Bournemouth v Brentford (19:30 GMT)
Bournemouth forward Evanilson is a doubt with a dead leg, and will be assessed after Monday night training.
Centre-back Marcos Senesi, who suffered a knock against Sunderland, is fit to play.
Brentford goalkeeper Caoimhin Kelleher is available again after paternity leave.
Winger Reiss Nelson missed the win over Burnley with a calf issue but will return to training this week.
Defender Aaron Hickey will be back from a hamstring problem after the international break, while Vitaly Janelt is expected to be sidelined for a few games with a metatarsal issue.
Players out:Brentford - Nelson, Janelt, Hickey, Dasilva, Milambo, Carvalho Bournemouth - Kluivert, Soler, Gannon-Doak, Cook
Doubts: Bournemouth - Evanilson
Key FPL notes:
- Only Burnley's Jaidon Anthony (£5.0m), with five, had more shots on goal in gameweek 28 than Bournemouth's Marcus Tavernier (£5.3m, four), who has produced attacking returns (two goals and an assist) in each of his last three starts.
- Across the last four matches, only five midfielders have had more shots than Bournemouth's January arrival Rayan (£5.6m, 11).
- Brentford's Igor Thiago (£7.1m) scored his 18th goal of the season in gameweek 28, placing him second in the scorers' charts behind the 22 of Manchester City's Erling Haaland (£14.8m). This season, only Haaland has had more big chances (33) than the Brazilian.
Everton v Burnley (19:30)
Everton captain Seamus Coleman has been ruled out with a knock but his absence is not expected to be for long.
Jack Grealish remains out with a foot problem while Charly Alcaraz is set to be sidelined until the end of the of month.
Burnley winger Marcus Edwards faces a late fitness test but the Clarets have no other new injuries.
Players out:Everton - Coleman, Alcaraz, Grealish
Burnley - Broja, Cullen, Beyer, Tuanzebe, Tresor, Roberts, Amdouni
Doubts: Burnley - Edwards
Key FPL notes:
- Since gameweek 19, only two forwards have scored more goals than Everton's Thierno Barry (£5.7m, five).
- Everton's James Tarkowski (£5.7m) has amassed 301 defensive contributions this season. This has earned him 36 defensive contribution points, which, among defenders, is only bettered by Bournemouth's Marcos Senesi (£4.9m).
- No player had more shots than the five of Burnley's Jaidon Anthony in gameweek 28, when he scored his seventh goal of the season.
- Who has made Troy's Premier League team of the week?
- Quiz: Name every team who has played in the Premier League
Leeds United v Sunderland (19:30)
Leeds United expect centre-back Joe Rodon to have shaken off a minor hamstring problem.
Full-back James Justin will be assessed after needing stitches to an injury suffered last weekend but is hoping to be fit.
Head coach Regis le Bris says Sunderland have no new injury updates, adding there would be late decisions on "one or two minor injuries".
Players out:Leeds - Okafor Sunderland - Mukiele, Brobbey, Ta Bi, Mundle, Cirkin, Reinildo.
Doubts: Leeds - Justin
Key FPL notes:
- Leeds United's Dominic Calvert-Lewin's (£5.8m) 53 shots and 22 big chances both rank top among Leeds players this season.
- Only one player created more chances than the four of Leeds United's Anton Stach (£4.7m) in gameweek 28. The German's 21 chances created in the last six home matches is bettered only by Manchester United's Bruno Fernandes (£9.9m)
- Across the last six gameweeks, no defender has picked up more defensive contribution points than the eight of Sunderland's Dan Ballard (£4.6m).
Wolves v Liverpool (20:15)
Wolves have a fully fit squad, as Hwang Hee-chan is available again after recovering from a calf strain he picked up against Chelsea last month.
Ladislav Krejci returns after serving a one-match ban on Friday.
Liverpool midfielder Florian Wirtz, who has been sidelined for the past two games with a back injury, is set to miss both league and cup fixtures against Wolves this week.
However, Reds head coach Arne Slot said he expected the German to be available again next week.
Players out:Liverpool - Wirtz, Isak, Endo, Bradley, Leoni
Key FPL notes:
- Over the last four gameweeks, no defender has picked up more defensive contribution points (six) than Wolves' Yerson Mosquera (£4.3m).
- Liverpool's Virgil van Dijk (£6.1m) has produced attacking returns in each of the last three gameweeks, amassing 35 points.
- Liverpool's Hugo Ekitike (£9.0m) was the second-highest scoring player in gameweek 28, with 15 points. The Frenchman is the most transferred-in player of the week so far.
Wednesday
Aston Villa v Chelsea (19:30)
Aston Villa team news will appear here on Wednesday.
Chelsea's Cole Palmer has shaken off a knock while Reece James is also fit to play.
Marc Cucurella has made good progress after a hamstring injury and could be in line to feature.
Wesley Fofana returns after a ban but Pedro Neto is suspended after his red card against Arsenal on Sunday.
Players out:Chelsea - Neto, Lavia, Gittens, Estevao, Colwill
Doubts: Chelsea - Cucurella
Key FPL notes:
- Aston Villa's Morgan Rogers' (£7.6m) 17 shots in the last six gameweeks are the joint-most of any FPL midfielder.
- In the last six gameweeks, only six midfielders have created more chances than the 12 of Villa's Douglas Luiz (£4.9m).
- In gameweek 28, only one player had more shots than Chelsea's Joao Pedro (£7.6m, four). The Brazilian is averaging 7.8 points per start since the appointment of Liam Rosenior.
Brighton & Hove Albion v Arsenal (19:30)
Team news will appear here on Wednesday.
Key FPL notes:
- After going five matches without a goal, Brighton's Danny Welbeck (£6.1m) has scored and earned maximum bonus points in consecutive matches.
- Arsenal's Jurrien Timber (£6.3m) responded to being the third most transferred-out player ahead of gameweek 28 with his second successive attacking return. He is the second-highest-scoring defender in the game with 135 points.
- Declan Rice (£7.5m) has recorded two assists in the last three gameweeks, but having felt "some discomfort", had to be substituted off in the latter stages of Arsenal's 2-1 victory over Chelsea.
Fulham v West Ham (19:30)
Fulham team news will appear here on Wednesday.
West Ham forward Pablo Felipe is "not yet" ready to return to training after being sidelined with a calf problem.
Midfielder Freddie Potts is suspended.
Players out:West Ham - Pablo, Potts
Key FPL notes:
- Across the last six home matches, only one midfielder has produced more goals than the four of Harry Wilson (£6.0m). However, the Fulham winger picked up an ankle injury before being taken off in the second half of Fulham's 2-1 win over Tottenham Hotspur on Sunday.
- Fulham's Alex Iwobi (£6.3m) has produced double-digit returns in each of the last two matches, amassing 23 points.
- West Ham's Crysencio Summerville (£5.7m) has scored four goals in the last seven gameweeks. In the last four away matches, no midfielder has attempted more shots (12) and only one has racked up more FPL points (29).
Manchester City v Nottingham Forest (19:30)
Team news will appear here on Wednesday.
Key FPL notes:
- Manchester City's Antoine Semenyo (£8.2m) is averaging 7.2 points per start over the last six gameweeks, thanks to four goals, one assist, two defensive contribution points and five bonus.
- Since arriving at Man City in gameweek 23, no defender has kept more clean sheets than Marc Guehi's (£5.2m) three.
- In the last four gameweeks, only one midfielder has created more chances than the 18 of Nottingham Forest's Morgan Gibbs-White (£7.3m).
Newcastle United v Manchester United (20:15)
Team news will appear here on Wednesday.
Key FPL notes:
- No defender has scored more goals than Newcastle's Malick Thiaw's (£5.0m) four this season.
- Manchester United's Bryan Mbeumo (£8.7m) has produced five attacking returns in seven gameweeks. In the last four away matches, only one midfielder has produced more shots (11) or had more big chances (four), while none have returned as many FPL points (30).
- Manchester United's Benjamin Sesko (£7.3m) marked his first start under Michael Carrick in gameweek 28 with his third successive goalscoring match.
Thursday
Tottenham v Crystal Palace (20:00)
Team news will appear here on Wednesday.
Key FPL notes:
- Tottenham's Xavi Simons' (£6.5m) 13 shots and 15 chances created over the last six gameweeks are both team-leading totals.
- In the last four home matches, Tottenham's Pedro Porro (£5.1m) has delivered 50 crosses, 29 more than any other defender.
- In the last four away matches, only one defender has created more chances than the nine of Crystal Palace's Daniel Munoz (£5.9m), while none have received more passes in the penalty area (12).