For High Score fantasy leagues, managers should target players against poor defenses while utilizing tools like FantasyPros' defensive vs. position tool to identify favorable matchups. Trading reliable players for volatile options before the deadline can provide championship upside, especially during bye weeks when managers can scout without pressure.
The key to success in High Score formats is recognizing that one explosive game can win a week, requiring a strategic shift from traditional points or 9-category leagues where consistency matters more. Waiver wire pickups with expanded roles and favorable defensive matchups present opportunities for late-season championship pushes.